Allergy risks of atopy/allergies, asthma, hay fever and eczema

Allergy has been assessed as protective factors for
several cancers including childhood leukemia. Evaluation of 1842 children
with acute lymphoblastic leukemia (ALL) showed that a history of eczema associated
with a significant reduction risk for cancer (odds ratio (OR)=0.7, 95% CI:0.5–0.9)
in a population-based case–control study in the USA(21). Also, history
of atopic dermatitis was related with significantly 50% lower risk for ALL and
not-significantly 20% decrement in the risk of acute myeloid leukemia (AML) (22). Controversy, a
study including 180 childhood ALL patients demonstrated no significant association
of childhood ALL with history of eczema (OR 1.1, 95% CI:0.6–2.0) (23). Studies investigating
association in adult leukemia have mixed results. A non-significant risk of chronic
lymphocytic leukemia(CLL) in adults with a history of eczema was announced in
USA population(24). A
population-based case-control study in Taiwan reported that any allergy and asthma
was related with an greater odds of childhood ALL (25).
Specifically,
in a meta-analysis performed in 2010 on childhood/adolescent ALL, the risks of
atopy/allergies, asthma, hay fever and eczema were 0.69, 0.79, 0.55, and 0.74
(95% CI: 0.54–0.89; 95% CI: 0.61–1.02; 95% CI:0.46–0.55; and 95% CI:0.58–0.96)
respectively(8). Recently, a
cohort population- based study in UK revealed that atopy is related with a 50 %
lower risk of CLL (relative risk (RR)=0.5, 95 % CI:0.3–0.8)(26).

Hodgkin lymphoma (HL) ,
malignancy of B-cell, is one of the most prevalent cancers in younger adults (27). It has been proposed that Allergy might be related
with an increased risk of HL, specifically among younger cases (28). Hollander et al found that history of allergic
rhinitis was correlated with a non-significantly lower risk of HL (OR = 0.81, 95
% CI:0.64 ,1.03;P = 0.09)(29). The results with a lower incidence of
self-reported Allergy in HL patients are compatible to observations in studies
of Non-Hodgkin lymphoma (NHL        

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